The hospital can trace its roots back to a workhouse on the same Hillsborough Road site that opened during the famine. The workhouse which was then known as the Lisburn Poor House, became the Lisburn and Hillsborough District Hospital in 1922. After a major extension, the hospital was renamed Lagan Valley Hospital in 1947. The hospital has seen great enlargement in years since, hastened by the closure of the geriatric units at Killowen and Lissue. At the turn of the millennium, the hospital was granted a new Accident and Emergency wing.